Thursday, February 18, 2010

We can TREAT HIV, but how about that "C word?"

New thinking about HIV eradication

We should do something cutting edge. 
Let's go for the whole thing.

Now that effective combination antiretroviral therapy has restored health and extended lives for many people with HIV, researchers and advocates are again turning their attention to a cure.

On February 4, the AIDS Policy Project, in conjunction with Project Inform, held its first scientific update on HIV eradication, bringing together local experts to provide an overview of an exclusive conference held this past December on the Caribbean island of St. Martin.

"Current drugs are not a panacea," said Matt Sharp, Project Inform's director of treatment and prevention advocacy, who has survived on them for two decades. "Antiretroviral therapy has made HIV a chronic manageable disease, but it's still not a cure."

While treatment has dramatically reduced illness and death from opportunistic infections due to immune system collapse, a growing body of evidence shows that even low-level HIV replication can wreak havoc throughout the body, perhaps by triggering chronic inflammation. This may explain higher rates of non-AIDS problems such as heart and liver disease in HIV-positive people, as well as what looks like accelerated aging.

Today's potent regimens can knock HIV in the blood down to an "undetectable" level in most people who achieve good adherence, but ultra-sensitive tests reveal that a small amount remains behind.

HIV inserts its genetic material into the DNA of latent or inactive T-cells, and there it remains until the cell is activated. Today's drugs can fight virus in the blood, but not sequestered in latent cells. The trick, therefore, is to "wake up" these reservoir cells, causing them to release virus and making them visible to the immune system.

The 4th International Workshop on HIV Persistence during Therapy brought together a small group of researchers from academia, government, and the pharmaceutical industry, along with community treatment advocates, to discuss the current state of eradication research.

Read the rest.

No comments:

Post a Comment

Related Posts Plugin for WordPress, Blogger...

select key words

2007 National HIV Prevention Conference 2009 National LGBTI Health Summit 2011 LGBTI Health Summit 2012 Gay Men's Health Summit 2012 International AIDS Conference abstinence only ACT Up activism advocacy Africa african-american aging issues AIDS AIDS Foundation of Chicago anal cancer anal carcinoma anal health anal sex andrew's anus athlete ball scene bareback porn barebacking bathhouses bears big bold and beautiful Bisexual Bisexual Health Summit bisexuality black gay men black msm blood ban blood donor body image bottom Brian Mustanski BUTT Center on Halsted Charles Stephens Chicago Chicago Black Gay Men's Caucus Chicago Task Force on LGBT Substance Use and Abuse Chris Bartlett chubby chaser circumcision civil rights civil union Coaching with Jake communication community organizing condoms Congress crystal meth dating dating and mating with alan irgang David Halperin David Munar depression disclosure discrimination domestic violence don't ask don't tell douche downlow Dr. James Holsinger Dr. Jesus Ramirez-Valles Dr. Rafael Diaz Dr. Ron Stall drag queen Ed Negron emotional health ENDA Eric Rofes exercise Feast of Fun Feel the love... female condom fitness Friday is for Faeries FTM gay culture gay identity gay latino gay male sex gay marriage gay men gay men of color gay men's health Gay Men's Health Summit 2010 gay pride gay rights gay rugby gay sex gay youth gender harm reduction hate crime HCV health care health care reform health insurance hepatitis C HIV HIV care HIV drugs HIV negative HIV positive HIV prevention HIV stigma HIV strategic plan HIV testing hiv vaccine HIV/AIDS homophobia homosexuality hottie hotties how are you healthy? Howard Brown Health Center HPV human rights humor hunk Illinois IML immigration International AIDS Conference international mr. leather internet intimacy IRMA Jim Pickett leather community leathersex Leon Liberman LGBT LGBT adoption LGBT culture LGBT health LGBT rights LGBT seniors LGBT youth LGBTI community LGBTI culture LGBTI health LGBTI rights LGBTI spirituality LGV LifeLube LifeLube forum LifeLube poll LifeLube subscription lifelube survey Lorenzo Herrera y Lozano love lube lubricant Lymphogranuloma Venereum masturbation mental health microbicides middle Monday Morning Perk-Up MRSA MSM music National AIDS Strategy National Gay Men's Health Summit negotiated safety nutrition One Fey's Tale oral sex Peter Pointers physical health Pistol Pete pleasure PnP podcast policy politics poppers porn post-exposure prophylaxis PrEP President Barack Obama Presidential Campaign prevention Project CRYSP prostate prostate cancer public health public sex venues queer identity racism Radical Faerie recovery rectal microbicides relationships religion research safe sex semen Senator Barack Obama sero-adaptation sero-sorting seroguessing sex sexual abuse sexual addiction sexual health sexual orientation Sister Glo Sisters of Perpetual Indulgence smoking social marketing spirituality STD stigma stonewall riots substance abuse treatment substance use suicide super-bug superinfection Susan Kingston Swiss declaration syphilis Ted Kerr Test Positive Aware Network testicle self-examination testicular cancer testing The "Work-In" The 2009 Gay Men's Health Agenda Tony Valenzuela top Trans and Intersex Association trans group blog Trans Gynecology Access Program transgender transgender day of remembrance transgendered transmen transphobia transsexual Trevor Hoppe universal health care unsafe sex vaccines video violence viral load Who's That Queer Woof Wednesday writers yoga You Tube youtube