Much of the research aimed at developing new therapeutic strategies for HIV deals with finding ways to limit the ability of the virus to make copies of itself. But in some situations, turning on the virus—activating its growth from silent or latent reservoirs resistant to antiretroviral drug attack—may be just as important, particularly in the search for strategies to eradicate the last vestiges of HIV. Two amfAR-funded scientists, Dr. David Margolis of the University of North Carolina at Chapel Hill and Dr. Miranda Shehu-Xhilaga of Monash University in Melbourne, Australia, addressed this concept in separate articles published this September in two issues of AIDS.
As paradoxical as it might seem, dialing up the growth of the virus may be a valid strategy in HIV-infected individuals who have been successfully treated with antiretroviral drugs.
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