via Aidsmap
...All these seven patients, as well as the two treatment-experienced patients, were gay men aged in their 20s – 40s. They all reported the use of methamphetamine and sex with multiple, mostly anonymous partners. Many of the men also reported the use of other recreational drugs as well as treatments for erectile dysfunction. At the time of HIV infection, many of the men were also infected with a bacterial sexually transmitted infection.
Investigators in Seattle have reported a cluster of nine HIV infections involving resistance to multiple drugs from all the three main classes of antiretrovirals. The report is published in the October 1st edition of the Journal of Acquired Immune Deficiency Syndromes.
Seven of the nine men were newly diagnosed with HIV, the other two men had chronic HIV infection and were receiving antiretroviral therapy. One of these cases appears to involve superinfection during antiretroviral therapy that had been suppressing viral load to undetectable levels.
All nine cases involved gay men with high risk sexual activity. None of the men experienced rapid HIV disease progression and one patient initiated a carefully selected antiretroviral regimen that suppressed his viral load to undetectable levels. Nevertheless, the investigators note that the strain of drug-resistant HIV infecting the men was very “fit” and highly transmissible.
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